By downloading, viewing and utilizing information from the AMGS calculator, visitors assume full responsibility for their own actions and any damages or liabilities that may result from the utilization of information obtained from the AMGS calculator. The Roundtable has used reasonable efforts in collecting, preparing and providing quality information and material, but does not warrant or guarantee the accuracy, completeness, adequacy or currency of the information contained in the AMGS calculator. The American Chemical Society Green Chemistry Institute’s Pharmaceutical Roundtable (“the Roundtable”) has created this AMGS calculator to inform and guide users towards greener methods. Use the following web link to read this paper. Others that tested the calculator with HPLC, UPLC, SFC or Preparative HPLC- or Preparative SFC- methods are listed as co-authors in the following Green Chemistry publication: The members that contributed to the development and launch of the calculator are: Michael Hicks (Merck, Rahway, NJ), Bill Farrell and Christine Aurigemma (Pfizer, San Diego, CA), Paul Ferguson (AstraZeneca, Macclesfield, UK), and Dave Constable, Isamir Martinez and Christiana Briddell (ACS GCI, Washington, DC). This calculator was developed from a Microsoft Excel-based program first developed by Laurent Lehman at Bristol-Myers Squibb, New Brunswick and further improved through development by members of the American Chemical Society (ACS) Green Chemistry Institute (GCI) Pharmaceutical Roundtable’s Analytical Chemistry team. Please e-mail for specific details on how to improve the AMGS, so we can address your comments in future iterations of the tool. It is not currently designed for gas chromatographic methods, although the team welcomes specific suggestions for future versions. This calculator is for determining liquid chromatography and SFC greenness scores only. Where both a resolution and a sensitivity solution are used, the total volume should be included for both solutions in the sensitivity solution entry. If this solution is prepared through serial dilution, please provide the total volume of dilutions used to make the final solution. Calculator displays usually show numbers in standard form in a particular way. The system suitability test (SST) is typically 0.05% (v/v) relative to the API reference standard. For example, the top pan balances in most schools and colleges usually. Yellow and red colors were used to highlight areas where the method could be improved for example, in the table above, the instrument energy could be reduced by shortening the method run time. These colors are meant as an indicator highlighting the highest contribution to the AMGS value. Math Expression Renderer, Plots, Unit Converter. Solve advanced problems in Physics, Mathematics and Engineering. The color coding is meant as a guideline that indicates if a specific energy score (of the three noted categories), tips the balance of the AMGS total % beyond a ~1/3 contribution. Free Online Scientific Notation Calculator. The team feels that having this metric available will provide an environmental impact awareness and encourage analysts to develop greener methods. The AMGS metric factors solvent health, safety, environmental impact and cumulative energy demand, instrument energy usage and method solvent waste to benchmark and compare one method to another. The lower the AMGS, the greener the method. without using your calculator (you will need to do this for real in Paper 1). It is not meant as an absolute measure of method greenness or as a means to reject a given method based on the finite score. A good teacher will encourage you to do this by challenging you to think. Chemistry Calculator is an easy-to-use suite of calculators, including the following: Ideal Gas Law, Boyle's Law, Charles Law, Gay-Lussac's Law, Combined Gas Law, Crude Protein Estimation, Crude Fibre Estimation, Molar Mass of Gas, Dilution of Solutions, Estimation of Calcium by Titration, Sand Silica Estimation, Equivalent Weight of Acid, Neutralization Reaction, Unknown Metal Weight, Oxidizing and Reducing Agents, Henderson Hasselbalch Equation, Soluble Protein Estimation, Hydrogen Ion Concentration, Enthalphy, Ether Extract Percentage, Fatty Acid, Equivalent Mass of Acid, Double Decomposition, Equivalent Oxygen Weight, Molarity, Avogadro's Number, Arrhenius Equation, Atomic Mass, Molar Heat (or Enthalpy) of Vaporization, Vapour Density of Gas, Molecular Mass using GMV Law, Mass Percent Chemical without Given Masses, Mass Percent Chemicals with Masses, Dilution Factor, Density of Liquid.This tool is intended as general metric guideline to compare methods during development.
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